LindySez: You can also make this Homemade Chili Colorado in your slow-cooker; once you have “greyed” the meat and added the sauce, put into the slow cooker and cook on low for 8 hours or high for 4. If you want to use a pressure cooker, you can do that as well. Use slightly less liquid when making in the pressure cooker, as it retains the moisture much better than other cooking methods. If you like your Chili Colorado a little more on the thick side; add 2 tablespoons of flour to the meat once its juice has rendered. Stir well, then proceed with the recipe.